Pinazepam


Generic Medicine Info
Indications and Dosage
Oral
Anxiety
Adult: 10 mg daily in 2 divided doses; may increase to 20 mg daily in severe cases.
Administration
May be taken with or without food.
Contraindications
Myasthenia gravis, acute narrow-angle glaucoma. Pregnancy.
Special Precautions
Patient with CV disease, blood dyscrasias. Hepatic impairment.
Adverse Reactions
Blood and lymphatic system disorders: Rarely, bone marrow depression.
Cardiac disorders: Palpitations, tachycardia.
Gastrointestinal disorders: Gastrointestinal disorders.
Hepatobiliary disorders: Rarely, liver damage.
Musculoskeletal and connective tissue disorders: Muscle weakness.
Nervous system disorders: Ataxia, dizziness, drowsiness.
Psychiatric disorders: Confusion.
Skin and subcutaneous tissue disorders: Rash.
Drug Interactions
Enhances the sedative effects of other CNS depressant drugs (e.g. opioids, sedating antihistamines, barbiturates).
Food Interaction
Increases the CNS depressant effects of alcohol.
Action
Description: Pinazepam, a long-acting benzodiazepine, has general properties similar to diazepam but with less toxicity. Its action mainly involves modification in the limbic system region. Pinazepam appears to be associated with a particularly low hypnotic effect and a limited motor coordination impairment. It also shows less cortical activity at the anxiolytic level than does diazepam on EEG.
Pharmacokinetics:
Absorption: Rapidly absorbed from the gastrointestinal tract.
Metabolism: Metabolised via N-1 dealkylation and C-3 hydroxylation.
Chemical Structure

Chemical Structure Image
Pinazepam

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 40391, Pinazepam. https://pubchem.ncbi.nlm.nih.gov/compound/Pinazepam. Accessed Dec. 28, 2021.

MIMS Class
Anxiolytics
ATC Classification
N05BA14 - pinazepam ; Belongs to the class of benzodiazepine derivatives anxiolytics. Used in the management of anxiety, agitation or tension.
References
Janbroers JM. Pinazepam: Review of Pharmacological Properties and Therapeutic Efficacy. Clin Ther. 1984;6(4):434-50. Accessed 15/11/2021. PMID: 6147192

Anon. Pinazepam. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 12/11/2021.

Buckingham R (ed). Pinazepam. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 12/11/2021.

Domar (Eurodrug). MIMS Hong Kong. http://www.mims.com/hongkong. Accessed 12/11/2021.

Domar (Eurodrug). MIMS Thailand. http://www.mims.com/thailand. Accessed 12/11/2021.

Preston CL (ed). Pinazepam Drug Interactions. Stockley’s Drug Interactions [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 15/11/2021.

Disclaimer: This information is independently developed by MIMS based on Pinazepam from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by MIMS.com
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