Pinazepam: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Myanmar prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Anxiety

Adult: 10 mg daily in 2 divided doses; may increase to 20 mg daily in severe cases.

Administration

May be taken with or without food.

Contraindications

Myasthenia gravis, acute narrow-angle glaucoma. Pregnancy.

Special Precautions

Patient with CV disease, blood dyscrasias. Hepatic impairment.

Adverse Reactions

Blood and lymphatic system disorders: Rarely, bone marrow depression.
Cardiac disorders: Palpitations, tachycardia.
Gastrointestinal disorders: Gastrointestinal disorders.
Hepatobiliary disorders: Rarely, liver damage.
Musculoskeletal and connective tissue disorders: Muscle weakness.
Nervous system disorders: Ataxia, dizziness, drowsiness.
Psychiatric disorders: Confusion.
Skin and subcutaneous tissue disorders: Rash.

Drug Interactions

Enhances the sedative effects of other CNS depressant drugs (e.g. opioids, sedating antihistamines, barbiturates).

Food Interaction

Increases the CNS depressant effects of alcohol.

Action

Description: Pinazepam, a long-acting benzodiazepine, has general properties similar to diazepam but with less toxicity. Its action mainly involves modification in the limbic system region. Pinazepam appears to be associated with a particularly low hypnotic effect and a limited motor coordination impairment. It also shows less cortical activity at the anxiolytic level than does diazepam on EEG.
Pharmacokinetics:
Absorption: Rapidly absorbed from the gastrointestinal tract.
Metabolism: Metabolised via N-1 dealkylation and C-3 hydroxylation.

Chemical Structure

MIMS Class

Anxiolytics

ATC Classification

N05BA14 - pinazepam ; Belongs to the class of benzodiazepine derivatives anxiolytics. Used in the management of anxiety, agitation or tension.

References

Janbroers JM. Pinazepam: Review of Pharmacological Properties and Therapeutic Efficacy. Clin Ther. 1984;6(4):434-50. Accessed 15/11/2021. PMID: 6147192

Anon. Pinazepam. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 12/11/2021.

Buckingham R (ed). Pinazepam. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 12/11/2021.

Domar (Eurodrug). MIMS Hong Kong. http://www.mims.com/hongkong. Accessed 12/11/2021.

Domar (Eurodrug). MIMS Thailand. http://www.mims.com/thailand. Accessed 12/11/2021.

Preston CL (ed). Pinazepam Drug Interactions. Stockley’s Drug Interactions [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 15/11/2021.

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