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Concomitant administration of rugs that reduce stomach acidity eg, anticholinergic agents, antacids and H2-receptor antagonists may reduce the absorption of ketoconazole. If indicated, these drugs should be taken not <2 hrs after ketoconazole.
Ketoconazole has been shown to increase plasma concentration of cyclosporin in patients receiving both drugs.
There are no clinical studies of drug interaction with ketoconazole ointment.
