Susceptible infections
Adult: 400 mg bid.
Oral
Acute uncomplicated cystitis in women, Gonococcal urethritis in men
Adult: 800 mg as single dose.
Indications and Dosage
Oral
Susceptible infections Adult: 400 mg bid. Oral Acute uncomplicated cystitis in women, Gonococcal urethritis in men Adult: 800 mg as single dose.
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Renal Impairment
Dose reduction may be necessary.
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Administration
Should be taken with food.
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Contraindications
Hypersensitivity to quinolones, children <12 yr, pregnancy, lactation.
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Special Precautions
Underlying CNS disease; hepatic disease; renal impairment. Avoid sun exposure, may cause severe sunburn.
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Adverse Reactions
Nausea, vomiting, gastric pain, dizziness, insomnia, allergic skin reactions, thrombocytopaenia, leukopenia/neutropenia, photosensitisation, arthropathy, muscular pain, headache, delusions, depression, hallucinations, hepatic dysfunction.
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Drug Interactions
Reduced absorption with antacids, didanosine (DDI), iron salts, pirenzepine, sucralfate, vincristine, zinc salts; increased levels with cimetidine, probenecid, theophylline; increases the levels of cyclosporine; causes seizures with foscarnet, NSAIDs, piroxicam; hypoglycemia with glimeperide; antagonistic with quercetin.
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Action
Description: Pefloxacin is a fluoroquinolone antibacterial that exhibits its bactericidal action by inhibition of DNA gyrase and topoisomerase IV which are needed for bacterial DNA reproduction.
Pharmacokinetics: Metabolism: Extensive metabolism; converted to N-desmethylpefloxacin (norfloxacin). Excretion: 8-13 hr (elimination half-life). |
Storage
Store at room temperature. Keep away from excess heat and moisture.
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MIMS Class
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