Pedolip Special Precautions

As with other antiplatelet agents, Clopidogrel should be used with caution in-patients who may be at risk of increased bleeding from trauma, surgery, or other pathological conditions. If a patient is to undergo elective surgery and an antiplatelet effect is not desired, Clopidogrel should be discontinued 5 days prior to surgery.
Clopidogrel prolongs the bleeding time. Patients should be told that it might take them longer than usual to stop bleeding when they take Clopidogrel, and that they should report any unusual bleeding to their physician.
Renally & Hepatically Impaired Patients: After repeated doses of Clopidogrel 75 mg per day, plasma levels of the main circulating metabolite were lower in patients with severe renal impairment (creatinine clearance from 5 to 15 mL/min) compared to subjects with moderate renal impairment (creatinine clearance 30 to 60 mL/min) or healthy subjects. No dosage adjustment is needed in renally impaired patients.
Clopidogrel should be used with caution in hepatically impaired patients.
Use in Children: Safety and effectiveness in the paediatric population have not been established.
Use in Elderly: No dosage adjustment is needed for the elderly.