Paromomycin: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Myanmar prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Hepatic encephalopathy

Adult: As adjunctive therapy: 4 g daily in divided doses at regular intervals for 5-6 days.

Oral
Intestinal amoebiasis

Adult: 25-35 mg/kg daily in 3 divided doses for 5-10 days.
Child: Same as adult dose.

Administration

Should be taken with food. Take during meals.

Contraindications

Hypersensitivity to paromomycin and other aminoglycosides. Intestinal obstruction.

Special Precautions

Patient w/ ulcerative bowel lesions. Prolonged use may result in overgrowth of non-susceptible organisms. Renal impairment. Pregnancy and lactation.

Adverse Reactions

Ototoxicity, anorexia, nausea, vomiting, epigastric burning and pain, increased GI motility, abdominal cramps, diarrhoea, pruritus ani, hypocholesterolaemia, malabsorption of xylose and sucrose, abnormal fat metabolism, headache, vertigo, eosinophilia, exanthema, unexplained haematuria.
Potentially Fatal: Pseudomembranous colitis, nephrotoxicity, neuromuscular blockade.

Pregnancy Category (US FDA)

PO: C

Action

Description: Paromomycin acts directly on amoeba. It has antibacterial activity against normal and pathogenic organisms in the GI tract and interferes w/ bacterial protein synthesis by binding to 30S ribosomal subunits.
Pharmacokinetics:
Absorption: Poorly absorbed from the GI tract.
Excretion: Via faeces (approx 100% of the dose, as unchanged drug); via urine (approx 0.1%).

Chemical Structure

Storage

Store between 15-30°C. Protect from moisture.

MIMS Class

Aminoglycosides / Antiamoebics

References

Anon. Paromomycin. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 22/10/2014.

Buckingham R (ed). Paromomycin Sulfate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 22/10/2014.

McEvoy GK, Snow EK, Miller J et al (eds). Paromomycin Sulfate . AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 22/10/2014.

Paromomycin Sulfate Capsule (Heritage Pharmaceuticals Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 22/10/2014.

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