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Indications and Dosage
Oral
Allergic conditions Adult: As acetate, with chlorphenamine maleate: 1 mg tid, may increase up to 6 mg in 24 hr. Child: As acetate, with chlorphenamine maleate: 6-14 yr: 0.5 mg 3 to 4 times a day; max: 4 mg/day. Oral Anti-inflammatory Adult: 2-24 mg/day
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Contraindications
Tuberculosis, fungal infection, herpes, bone disease, thyroid disease, colitis, peptic ulcer, diabetes, myasthenia gravis, liver or kidney disease, diverticulitis, glaucoma, heart disease. Pregnancy.
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Special Precautions
Elderly, children, lactation. Avoid abrupt discontinuation, immunisation. Monitor growth in children.
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Adverse Reactions
Acne, poor wound healing, indigestion, nausea, vomiting, thirst, constipation, gaseousness, unpleasant taste, diarrhoea, headache, cough, dizziness, hoarseness, appetite gain or loss. Prolonged use: growth retardation in children, glaucoma, cataracts, diabetes, fragile bones, thin skin, functional dependence.
Potentially Fatal: Anaphylaxis. |
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Overdosage
Headache, convulsions, heart failure.
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Drug Interactions
Decreased effects with anticonvulsants, antihistamine, barbiturates, chloral hydrate, ephedrine, rifampin. Increased effects with NSAID, contraceptives, indomethacin, tobacco. Decreases effects of anticoagulants, antidiabetics, cholinergics, insulin, isoniazid, salicylates, potassium. Increases effects of theophylline. Increased risk of hypokalemia with amphotericin, chlorthalidone, thiazide diuretics, furosemide, digitalis preparations (possible digitalis toxicity). Increased risk of stomach ulcers with alcohol.
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Action
Description: Paramethasone is a corticosteroid, used systemically for its glucocorticoid activity. 2 mg paramethasone is equivalent in anti-inflammatory activity to 5 mg prednisolone.
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MIMS Class
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