Pancreatin: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Myanmar prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Pancreatic insufficiency

Adult: Dose is adjusted according to dosage form and patient's needs. Usual dose with each meal: 5,000-56,000 units of lipase activity (with varying proportions of protease and amylase activity, depending on the preparation).
Child: Dose dependant upon dosage form and patient's needs. Children with cystic fibrosis max dose: 10,000 units lipase/kg/day.

Contraindications

Acute pancreatitis or acute exacerbation of chronic pancreatic disease.

Special Precautions

Avoid high doses in patients with cystic fibrosis. Maintain adequate hydration. Some products contain pork protein. Inactivated by heat; do not mix with hot food or liquids. May irritate oral mucosa; should not be held in mouth. Pregnancy and lactation.

Adverse Reactions

GI effects e.g. abdominal discomfort, nausea and vomiting. Buccal and perianal irritation, particularly in infants. Colonic strictures may occur, mainly in children with cystic fibrosis receiving high doses of pancreatin preparations. Hyperuricaemia and hyperuricosuria may occur.

Overdosage

May lead to laxative effect; treatment: supportive.

Drug Interactions

May impair the oral absorption of folic acid when taken together; antagonises hypoglycaemic effect of acarbose.

Action

Description: Pancreatin are pancreatic enzymes which hydrolyse fats to glycerol and fatty acids, break down protein into peptides, proteoses and derived substances, and convert starch into dextrins and sugars.

Storage

Store at 15-30°C. Protect from humidity.

MIMS Class

Digestives

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