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Pregnancy: For Palonosetron no clinical data on exposed pregnancies are available. Animal studies do not indicate direct or indirect harmful effects with respect to pregnancy, embryonal/foetal development, parturition or postnatal development. Only limited data from animal studies are available regarding the placental transfer.
There is no experience of palonosetron in human pregnancy. Therefore, palonosetron should not be used in pregnant women unless it is considered essential by the physician.
Breast-feeding: As there are no data concerning palonosetron excretion in breast milk, breast-feeding should be discontinued during therapy.
Fertility: There are no data concerning the effect of palonosetron on fertility.
