Palohalt Dosage/Direction for Use

Palonosetron Hydrochloride should be used only before chemotherapy administration. This medicinal product should be administered by a healthcare professional under appropriate medical supervision.
Posology: Adults: Moderately emetogenic chemotherapy: ADULT over 18 years, by mouth 500 micrograms 1 hour before treatment or by intravenous injection (over 30 seconds) 250 micrograms as a single dose 30 minutes before treatment.
Severely emetogenic chemotherapy: ADULT over 18 years, by intravenous injection (over 30 seconds) 250 micrograms as a single dose 30 minutes before treatment.
The efficacy of Palonosetron Hydrochloride in the prevention of nausea and vomiting induced by highly emetogenic chemotherapy may be enhanced by the addition of a corticosteroid administered prior to chemotherapy.
Elderly population: No dose adjustment is necessary for the elderly.
Paediatric population: The safety and efficacy in children have not been established. Current available data are described in Pharmacology: Pharmacodynamics and Pharmacokinetics under Actions, but no recommendation on posology can be made.
Hepatic impairment: No dose adjustment is necessary for patients with impaired hepatic function.
Renal impairment: No dose adjustment is necessary for patients with impaired renal function.
No data are available for patients with end stage renal disease undergoing haemodialysis.
Method of administration: For intravenous use.