Pacxime should be given with caution to patients who have shown hypersensitivity to other medicines. Cephalosporins should be given with caution to penicillin-sensitive patients as there are some evidence of partial cross-allergenicity between penicillins and cephalosporins.
If an allergic effect occurs with Pacxime, discontinue treatment and treat patient with appropriate agents if necessary.
Pacxime should be administered with caution in patients with markedly-impaired renal function.
Prolonged use of Pacxime may result in the overgrowth of nonsusceptible organisms. Cefixime has been shown to alter the normal flora of the colon and may permit overgrowth of Clostridia. Studies indicate that a toxin/s produced by Clostridium difficile is the primary cause of antibiotic-associated pseudomembranous colitis. Pacxime should be discontinued if diarrhoea occurs.
Use in pregnancy and lactation: Safe use in human pregnancy has not been established and it is not known whether cefixime is excreted in human breastmilk.