Divide daily doses w/ 6-hr interval. Duration: 2-6 mth for skin & hair infections; 6-9 mth for fingernails; at least 1 yr for toenails. Adult 500 mg-1 g 24 hrly. Severe or extensive infections 1.5-2 g 24 hrly for short periods. Childn 10 mg/kg 24 hrly.
Men should not father childn w/in 6 mth of treatment. Alcohol intake. May precipitate or aggravate SLE. May impair ability to drive or operate machinery.
Headache, skin rashes, dry mouth, altered sensation of taste, GI disturbances.
Drug Interactions
Decreased GI absorption w/ phenobarbitone. May increase rate of metabolism & diminish side effects of coumarin anticoagulants & OCs. Reduced plasma conc of salicylates. May enhance effects of alcohol.