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Clostridium difficile-associated diarrhea (CDAD) has been reported for nearly all antibacterial agents including Pacferatam and may range in severity from mild diarrhea to fatal colitis. Treatment with anti-infectives alters normal colon flora and may permit overgrowth of C. difficile. Clostridium difficile produces toxin A and B which process CDAD. Hypertoxin-producing strains of C. difficile are associated with increased morbidity and mortality since they may be refractory to anti-infectives and colectomy may be required. Consider CDAD if diarrhea develops during or after therapy and manage accordingly.
Careful medical history is necessary because CDAD has been reported to occur >2 months after the administration of antibacterial agents. If CDAD is suspected or confirmed, antibacterials not directed against C. difficile should be discontinued, if possible.
