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Indications and Dosage
Oral
Hypersensitivity reactions, Pruritic skin disorders Adult: 5-13 mg daily in divided doses.
Child: 0-3 mth: 2.5-5 mg/day; >3 mth: 5-20 mg/day. Doses to be taken in 2-3 divided doses. |
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Contraindications
Prostatic adenoma, angle-closure glaucoma, paralytic ileus, pyloric stenosis, myasthenia, status asthmaticus, COPD.
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Special Precautions
May impair ability to drive or operate machinery. Renal and hepatic impairment. Pregnancy and lactation. Children <1 yr. Elderly.
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Adverse Reactions
Gynaecomastia, rash, photosensitivity, urinary retention, dry mouth, constipation, orofacial dyskinesia, somnolence, headache, vertigo, muscular hyptonia.
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Drug Interactions
Additive CNS depression with alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives.
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Lab Interference
May interfere with skin testing.
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Action
Description: Oxomemazine, a phenothiazine derivative, is a sedating antihistamine. It competitively binds to histamine (H1) receptors, resulting in inhibition of the pharmacological effects of histamines. It also has some sedative, anticholinergic and antiserotoninergic effects.
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MIMS Class
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