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Indications and Dosage
Oral
Degenerative joint disorders, Inflammatory connective tissue diseases Adult: 200 mg tid. In severe cases, initial dose can be increased to 400 mg tid. Taken before a meal, unchewed. Elderly: Dose reduction is recommended. Topical/Cutaneous Superficial burns Adult: 10% cream: Apply once a day.
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Contraindications
Cream: infected skin lesions.
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Special Precautions
Children, elderly, pregnancy, lactation.
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Adverse Reactions
Gastric pain, nausea, diarrhoea, dizziness, headache and skin rashes.
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Overdosage
Sedation, ptosis, piloerection.
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Drug Interactions
Affects coagulation in patients under anticoagulative therapy with Vitamin K-antagonists. May decrease effects of anti-hypertensives. May affect toxicity of methotrexate and lithium.
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Action
Description: The exact mechanism of action of oxaceprol is not known. It affects connective tissue metabolism and has been used in dermatology, to promote wound healing, and in rheumatic disorders. Experimental models of arthritis showed that oxaceprol reduced leukocyte extravasation, as well as the adhesion of leukocytes to capillaries. In vitro studies have shown that oxaceprol stimulates the uptake of 3H-glucosamine and 3H-proline in chondrocytes and the incorporation of 3H-proline in the macromolecular structure of the matrix of cartilage; which would be responsible for the activity on regenerating tissue.
Pharmacokinetics: Absorption: 3.5 hr after oral admin. Distribution: Permeates into the synovial fluid. Bio-availability after oral admin: approx 30%. Excretion: Via urine (exclusively, unchanged and complete). Elimination half-life: 2.2 hr. |
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