Osteorise

Osteorise Overdosage

risedronic acid

Manufacturer:

CCL Pharma

Distributor:

Manawhari
Full Prescribing Info
Overdosage
Symptoms: Decreases in serum calcium following substantial overdose may be expected in some patients.
Signs and symptoms of hypocalcemia may also occur in some of these patients.
Lethality after single oral doses was seen in female rats at 903 mg/kg and male rats at 1703 mg/kg. The minimum lethal dose in mice and rabbits was 4000 mg/kg and 1000 mg/kg. These values represent 320 to 620 times the 30-mg human dose based on surface area (mg/m2).
Treatment: Administration of milk or antacids containing calcium may be helpful to chelate risedronate and reduce absorption of drug. In cases of substantial overdose, gastric lavage may be considered to remove unabsorbed drug if performed within 30 minutes of ingestion. Standard procedures that are effective for treating hypocalcemia, including the administration of calcium i.v., would be expected to restore physiologic amounts of ionized calcium and to relieve signs and symptoms of hypocalcemia.
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