Osteorise Drug Interactions

No specific drug-drug interaction studies were performed. Risedronate is not metabolized and does not induce or inhibit hepatic microsomal drug-metabolizing enzymes (Cytochrome P450).
Calcium Supplements/Antacids: Co-administration of Risedronate Sodium (Osteorise) and calcium, antacids, or oral medications containing divalent cations will interfere with the absorption of Risedronate Sodium (Osteorise).
Hormone Replacement Therapy: If considered appropriate, Risedronate Sodium (Osteorise) may be used concomitantly with hormone replacement therapy.
Aspirin/Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Among regular aspirin or NSAID users, the incidence of upper gastrointestinal adverse experiences in Risedronate Sodium (Osteorise)-treated patients is similar to that of placebo.
H2 Blockers and Proton Pump Inhibitors (PPIs): In such patients using PPIs or H2 blockers, the incidence of upper gastrointestinal adverse experiences in the Risedronate Sodium (Osteorise)-treated patients was similar to that in placebo-treated patients.
Drug/Laboratory Test Interactions: Bisphosphonates are known to interfere with the use of bone-imaging agents. Specific studies with Risedronate Sodium (Osteorise) have not been performed.