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Contraindications
Pre-existing hypertension; occlusive vascular disease; phaeochromocytoma; angle-closure glaucoma (eye drops); hypersensitivity; cardiac arrhythmias.
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Special Precautions
CV diseases; hyperthyroidism; DM; Parkinson's disease; elderly; pregnancy, lactation, prostate disorders.
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Adverse Reactions
CNS effects; GI disturbances; epigastric pain; CV disorders; difficulty in micturition with urinary retention; dyspnoea; hyperglycaemia; sweating; hypersalivation; weakness, tremors; coldness of extremities; hypokalaemia, tachycardia, reflex bradycardia. Gangrene, tissue necrosis and sloughing (extravasation), especially when used in addition to local anaesthetics.
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Drug Interactions
May antagonise effects of antihypertensives, guanethidine. Increased risk of ventricular fibrillation with inhalational anaesthetics. Pressor effects may be enhanced by ergot alkaloids or oxytocin. Additive toxicity may occur with antiparkinsonian drugs.
Potentially Fatal: Severe hypertension with MAOIs and other sympathomimetics. |
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Action
Description: Octopamine is a sympathomimetic with predominantly α-adrenergic activity used in the treatment of hypotensive states.
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MIMS Class
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