Norgetex

Norgetex Mechanism of Action

orphenadrine + paracetamol

Manufacturer:

Favorex

Distributor:

DKSH
Full Prescribing Info
Action
Pharmacology: Orphenadrine is a centrally-acting potent skeletal muscle relaxant by blocking reticular facilitation whose hyperactivity leads to spasticity, rigidity and muscle spasm. It does not affect normal muscle tone and voluntary movement. Action is rapid in onset and relatively prolonged. It also possesses anticholinergic properties and this acts by blocking the effect of acetylcholine in CNS.
The combination of anticholinergic effects and CNS penetration make orphenadrine useful for pain of all etiologies including pain from radiculopathy, muscle pain, headaches and many others.
Paracetamol has antipyretic, analgesic and weak anti-inflammatory properties by inhibiting prostaglandin synthesis in CNS and peripheral tissues.
Pharmacokinetics: Orphenadrine is readily absorbed from the GIT and has bioavailability of 90%. The t½ is approximately 13-20 hrs and it is metabolized in the liver by hepatic demethylation. Excretion is via renal and biliary tracts.
Paracetamol is rapidly absorbed from the GIT primarily in small gut by passive transport. It is metabolized primarily by 1st order kinetics. Massive plasma levels occur within 20-90 min after ingestion. It is metabolized in the liver by conjugation with glucuronic acid and to a lesser extent with sulfuric acid. Paracetamol appear to be distributed throughout most body fluid except fat and cerebrospinal fluid. The biological t½ of paracetamol in normal adults is about 2-3 hrs in usual dosage range.
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