Norditropin NordiFlex

Norditropin NordiFlex Drug Interactions



Novo Nordisk


Full Prescribing Info
Drug Interactions
Concomitant treatment with glucocorticoids inhibits the growth-promoting effects of Norditropin.
Patients with ACTH deficiency should have their glucocorticoid replacement therapy carefully adjusted to avoid any inhibitory effect on growth.
Growth hormone decreases the conversion of cortisone to cortisol and may unmask previously undiscovered central hypoadrenalism or render low glucocorticoid replacement doses ineffective (see Precautions).
In women on oral oestrogen replacement, a higher dose of growth hormone may be required to achieve the treatment goal (see Precautions).
Data from an interaction study performed in growth hormone deficient adults, suggests that somatropin administration may increase the clearance of compounds known to be metabolised by cytochrome P450 isoenzymes. The clearance of compounds metabolised by cytochrome P450 3A4 (e.g. sex steroids, corticosteroids, anticonvulsants and cyclosporine) may be especially increased resulting in lower plasma levels of these compounds. The clinical significance of this is unknown.
The effect of somatropin on final height can also be influenced by additional therapy with other hormones, e.g. gonadotrophin, anabolic steroids, estrogen, and thyroid hormone.
In insulin treated patients adjustment of insulin dose may be needed after initiation of somatropin treatment (see Precautions).
Paediatric population: Interaction studies have only been performed in adults.
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