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Indications and Dosage
Oral
Amoebiasis Adult: 1 g bid for 5-10 days. Oral Giardiasis Adult: 500 mg bid for 5-7 days. Oral Trichomoniasis Adult: 2 g as a single dose. Alternatively, 1 g every 12 hr for 3 doses or 250 mg tid for 5-7 days. Sexual partners should be treated concomitantly. Oral Acute ulcerative gingivitis Adult: 500 mg bid for 2 days.
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Contraindications
Pregnancy and lactation.
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Special Precautions
Blood dyscrasias; active disease of the CNS.
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Adverse Reactions
Nausea, vomiting, diarrhoea, anorexia, epigastric pain, vertigo, somnolence, rash, pruritus.
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Drug Interactions
Disulfiram-like reaction may occur with alcohol.
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Action
Description: Nimorazole is an antimicrobial with activity against anaerobic bacteria and protozoa. Its actions and properties are similar to metronidazole.
Pharmacokinetics: Absorption: Readily absorbed from the GI tract. Peak plasma levels within 2 hr. Distribution: High levels reported to occur in salivary and vaginal secretions; distributes in breast milk. Excretion: Via urine (as unchanged drug and 2 active metabolites). |
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MIMS Class
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