Reversal of central depression from opioid use during surgery
Adult: As naloxone hydrochloride: 100-200 mcg, may give additional 100 mcg if necessary at 2-3 minute intervals until adequate response is obtained. Dose may be repeated within 1-2 hours depending on the dose, type and time interval of last opioid administration.
Child: As naloxone hydrochloride: 10-20 mcg/kg at 2-3 minute intervals until adequate response is obtained. May give additional dose if necessary at 1-2 hours interval depending on the dose, type and time interval of last opioid administration.
Child: As naloxone hydrochloride: 10-20 mcg/kg at 2-3 minute intervals until adequate response is obtained. May give additional dose if necessary at 1-2 hours interval depending on the dose, type and time interval of last opioid administration.
Intravenous
Opioid overdosage
Adult: As naloxone hydrochloride: 0.4-2 mg repeated if necessary at 2-3 minute intervals. If there is no response after a total of 10 mg has been given, consider the possibility of overdosage with other drugs.
Child: As naloxone hydrochloride: Initially, 10 mcg/kg followed by 100 mcg/kg , if necessary. Alternatively, may be given via IM inj, if IV admin is not possible.
Child: As naloxone hydrochloride: Initially, 10 mcg/kg followed by 100 mcg/kg , if necessary. Alternatively, may be given via IM inj, if IV admin is not possible.
Oral
Opioid dependence
Adult: As hydrochloride: 200 mg to 3 g daily.
Parenteral
Opioid-induced respiratory depression in neonates due to obstetric analgesia
Child: As naloxone hydrochloride: 10 mcg/kg via IV or IM inj, may be repeated at 2-3 minute intervals if necessary.