Prophylaxis of clotting in the extracorporeal circulation during haemodialysis
Adult: In haemodialysis sessions lasting <4 hours: As 9,500 anti-Xa IU/mL inj in patients weighing <50 kg: 2,850 anti-Xa IU; 50-69 kg: 3,800 anti-Xa IU; ≥70 kg: 5,700 anti-Xa IU. Doses are administered as a single dose into the arterial line of the circuit at the start of dialysis. May give additional dose if session last for >4 hours. Adjust dose in subsequent dialysis sessions as necessary according to patient response. In patients at high risk of haemorrhage: Reduce dose to half.
Intravenous, Subcutaneous
Non-Q wave myocardial infarction, Unstable angina
Adult: As 9,500 anti-Xa IU/mL inj in combination with aspirin: Initially, 86 anti-Xa IU/kg given via IV bolus inj. Subsequent doses are given via SC inj 12 hourly. Usual treatment duration: 6 days. Dosage may be adjusted according to individual bodyweight (refer to detailed product guidelines).
Subcutaneous
Prophylaxis of thromboembolic disorder
Adult: As 9,500 anti-Xa IU/mL inj: For general surgery: Initially, 2,850 anti-Xa IU given 2-4 hours prior to surgery, then once daily on subsequent days for at least 7 days or until the patient is ambulant. For orthopaedic surgery: Initially, 38 anti-Xa IU/kg given 12 hours before, and 12 hours after surgery, then once daily until Day 3 post-op. Then, increase dose by 50% or up to 57 anti-Xa IU/kg once daily starting Day 4 post-op. Continue treatment until the patient is ambulant for at least 10 days. For high-risk patients weighing ≤70 kg: 3,800 anti-Xa IU once daily; >70 kg: 5,700 anti-Xa IU once daily. Continue treatment throughout the risk period.
Elderly: For high-risk patients: May reduce dose to 2,850 anti-Xa IU once daily.
Elderly: For high-risk patients: May reduce dose to 2,850 anti-Xa IU once daily.
Subcutaneous
Thromboembolic disorders
Adult: As 9,500 anti-Xa IU/mL inj: 86 anti-Xa IU/kg 12 hourly. As 19,000 anti-Xa IU/mL inj: 171 anti-Xa IU/kg once daily. Usual treatment duration: 10 days. Dosage is adjusted according to individual bodyweight (refer to detailed product guidelines).