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Reproduction studies have been performed in rats and rabbits at systemic doses ie, orally, SC and IM, up to 100 times the human topical dose and have revealed no evidence of impaired fertility or harm to the fetus due to mupirocin. There are, however, no adequate and well-controlled studies in pregnant women. Because animal studies are not always predictive of human response, mupirocin should be used during pregnancy only if clearly needed.
It is not known whether mupirocin is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when mupirocin is given to nursing mothers.
