Motilium Dosage/Direction for Use

It is recommended to take oral MOTILIUM 15-30 minutes before meals. If taken after meals, absorption of the drug is somewhat delayed.
Prescription use: When MOTILIUM is used on prescription, the following dosing information applies: Adults and adolescents ≥ 12 years of age and weighing ≥ 35 kg, and children weighing ≥ 35 kg: The dose of MOTILIUM should be the lowest effective dose for the individual situation (typically 30 mg/day) and can be increased if necessary to a maximum daily oral dose of 40 mg.
Usually, the maximum treatment duration should not exceed one week for the treatment of acute nausea and vomiting. If nausea and vomiting persists for longer than one week, patients should consult their physician. For other indications, the initial duration of treatment is up to four weeks. If treatment exceeds four weeks, patients should be reevaluated and the need for continued treatment reassessed. (See Table 2.)

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Infants and children < 12 years of age and weighing < 35 kg, and adults and adolescents weighing < 35 kg: The dose of MOTILIUM should be the lowest effective dose. The total daily dose is dependent on body weight (see table as follows). Since metabolic functions and the blood-brain barrier are not fully developed in the first months of life, the risk of neurological side effects is higher in young children (see Adverse Reactions). Overdosing may cause nervous system disorders in children (see Overdosage). The dose should be determined accurately based on body weight and not exceed the recommended maximum individual and daily dose in neonates, infants, toddlers and children.
Usually, the maximum treatment duration should not exceed one week for the treatment of acute nausea and vomiting. For other indications, the initial duration of treatment is up to four weeks. If treatment exceeds four weeks, patients should be reevaluated and the need for continued treatment reassessed. (See Table 3.)

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Renal impairment: Since the elimination half-life of domperidone is prolonged in severe renal impairment (serum creatinine > 6 mg/100 mL, i.e. > 0.6 mmol/L), the dosing frequency of MOTILIUM should be reduced to once or twice daily, depending on the severity of the impairment, and the dose may need to be reduced. Patients with severe renal impairment should be reviewed regularly (see Pharmacology: Pharmacokinetics under Actions).
Hepatic impairment: MOTILIUM is contraindicated for patients with moderate (Child-Pugh 7 to 9) or severe (Child-Pugh >9) hepatic impairment (see Contraindications). Dose adjustment is not required for patients with mild (Child-Pugh 5 to 6) hepatic impairment (see Pharmacology: Pharmacokinetics under Actions).