Inoperable adrenocortical tumours
Adult: Initially, 2-3 g daily in 2-3 divided doses; may be reduced to 1-2 g daily after 2 mth of treatment or until cumulative dose of 200 g or in the event of toxicity. If plasma monitoring is available, initial dose may be 4-6 g in divided doses to a cumulative dose of 75 g (over about 15 days). Other dose recommendation: Initially, 2-6 g daily in 3-4 divided doses; increase to 9-10 g daily unless adverse effects necessitate dose reduction. Max tolerated dose: 2-16 g daily.
Child: Initially, 1.5-3.5 g/m2 daily in 2-3 divided doses; reduce after 2-3 mth depending on plasma levels.
Child: Initially, 1.5-3.5 g/m2 daily in 2-3 divided doses; reduce after 2-3 mth depending on plasma levels.
Oral
Cushing's syndrome
Adult: 1-12 g daily. Secondary to pituitary disorders: Initially, 3-6 g daily in 3-4 divided doses. Maintenance: 500 mg twice wkly to 2 g daily.