Microflox Mechanism of Action

Fluoroquinolone antibiotic.
Pharmacology: Ciprofloxacin is bactericidal and acts by inhibiting the A subunit of DNA gyrase (topoisomerase) which is essential in the reproduction of bacterial DNA.
Ciprofloxacin is highly active in vitro against most gram-negative aerobic bacteria including Enterobacteriaceae, Haemophilus, Neisseriae and Pseudomonas aeruginosa. Ciprofloxacin is also active in vitro against many gram-positive aerobic bacteria, including penicillinase- and nonpenicillinase-producing and methicillin-resistant staphylococci. Many strains of streptococci are relatively resistant to ciprofloxacin. The in vitro antimicrobial activity of ciprofloxacin is not affected by the presence of pus.
Pharmacokinetics: Ciprofloxacin is rapidly absorbed, C_max ranges between 1.5-2 mg/L with t_max of about 60-75 min. It is widely distributed into body fluids and tissues except CSF, metabolised in the body and eliminated mainly by kidney. Half-life is about 4 hrs. Ciprofloxacin crosses into foetal blood and is excreted into breast milk.