Sign Out
Prophylaxis of postoperative anaerobic bacterial infections
Adult: 1,000-1,500 mg once daily for 30-60 minutes preoperatively. Alternatively, 500 mg immediately prior, during or after operation, then 500 mg 8 hourly for 24 hours.
Child: <12 years 20-30 mg/kg as single dose given 1-2 hours prior surgery.
Child: <12 years 20-30 mg/kg as single dose given 1-2 hours prior surgery.
Intravenous
Anaerobic bacterial infections
Adult: 1,000-1,500 mg once daily as single dose. Alternatively, 500 mg 8 hourly via infusion at a rate of 5 mL/min over 20-60 minutes usually for about 7 days. Max: 4,000 mg daily. Substitute oral therapy as soon as possible.
Child: 8 weeks 15 mg/kg once daily or divided into 7.5 mg/kg 12 hourly. >8 weeks to 12 years 20-30 mg/kg as a single dose or divided into 7.5 mg/kg 8 hourly. Treatment duration: Usually, 7 days. Daily dose may be increased to 40 mg/kg based on the severity of the infection.
Child: 8 weeks 15 mg/kg once daily or divided into 7.5 mg/kg 12 hourly. >8 weeks to 12 years 20-30 mg/kg as a single dose or divided into 7.5 mg/kg 8 hourly. Treatment duration: Usually, 7 days. Daily dose may be increased to 40 mg/kg based on the severity of the infection.
Oral
Acute dental infections
Adult: 200 mg tid for 3-7 days.
Oral
Eradication of H. pylori associated with peptic ulcer disease
Adult: In combination with another antibacterial and PPI: 400 mg bid for 7-14 days. In combination with omeprazole and amoxicillin: 400 mg tid. Consult official guidelines before initiating therapy.
Child: In combination with another antibacterial and PPI: 20 mg/kg daily in divided doses for 7-14 days. Max 500 mg bid.
Child: In combination with another antibacterial and PPI: 20 mg/kg daily in divided doses for 7-14 days. Max 500 mg bid.
Oral
Trichomoniasis
Adult: 2,000 mg as a single dose or 200 mg tid for 7 days. Alternatively, 400 mg bid for 5-7 days. Sexual partners should also be treated.
Child: 40 mg/kg as single dose or 15-30 mg/kg daily in 2-3 divided doses. Max: 2,000 mg/dose.
Child: 40 mg/kg as single dose or 15-30 mg/kg daily in 2-3 divided doses. Max: 2,000 mg/dose.
Oral
Prophylaxis of postoperative anaerobic bacterial infections
Adult: 400 mg 8 hourly in the 24 hours before surgery followed by IV or rectal dosage post-operatively until oral therapy is possible. Max: 4,000 mg daily.
Child: Newborn <40 weeks 10 mg/kg as single dose before surgery. <12 years 20-30 mg/kg as a single dose given 1-2 hours before surgery.
Child: Newborn <40 weeks 10 mg/kg as single dose before surgery. <12 years 20-30 mg/kg as a single dose given 1-2 hours before surgery.
Oral
Leg ulcer, Pressure sore
Adult: 400 mg tid for 7 days.
Oral
Giardiasis
Adult: 2,000 mg once daily for 3 days or 400 mg tid for 5 days or 500 mg bid for 7-10 days. Alternatively, 15-40 mg/kg daily in 2-3 divided doses.
Child: 1-3 years 50 mg once daily for 3 days. >3-7 years 600-800 mg once daily for 3 days; >7-10 years 1,000 mg once daily for 3 days. >10 years Same as adult dose. Alternatively, 15-40 mg/kg daily in 2-3 divided doses.
Child: 1-3 years 50 mg once daily for 3 days. >3-7 years 600-800 mg once daily for 3 days; >7-10 years 1,000 mg once daily for 3 days. >10 years Same as adult dose. Alternatively, 15-40 mg/kg daily in 2-3 divided doses.
Oral
Amoebiasis
Adult: 800 mg tid 5 days (intestinal infection); 400-800 mg for 5-10 days (extra-intestinal infection). Alternatively, 35-50 mg /kg daily in 3 divided doses for 5-10 days. Max: 2,400 mg daily.
Child: 1-3 years 200 mg tid for 5 days (intestinal); 100-200 mg tid for 5-10 days. 3-7 years 200 mg 4 times daily for 5 days (extra-intestinal); 100-200 mg 4 times daily for 5-10 days. 7-10 years 400 mg tid for 5 days (extra-intestinal); 400-800 tid for 5-10 days. Alternatively, 35-50 mg/kg daily in 3 divided doses for 5-10 days. Max: 2,400 mg daily.
Child: 1-3 years 200 mg tid for 5 days (intestinal); 100-200 mg tid for 5-10 days. 3-7 years 200 mg 4 times daily for 5 days (extra-intestinal); 100-200 mg 4 times daily for 5-10 days. 7-10 years 400 mg tid for 5 days (extra-intestinal); 400-800 tid for 5-10 days. Alternatively, 35-50 mg/kg daily in 3 divided doses for 5-10 days. Max: 2,400 mg daily.
Oral
Acute ulcerative gingivitis
Adult: 200 mg tid for 3 days.
Child: 1-3 years 50 mg tid for 3 days. >3-7 years 100 mg bid for 3 days; >7-10 years 100 mg tid for 3 days. >10 years Same as adult dose.
Child: 1-3 years 50 mg tid for 3 days. >3-7 years 100 mg bid for 3 days; >7-10 years 100 mg tid for 3 days. >10 years Same as adult dose.
Oral
Anaerobic bacterial infections
Adult: Initially, 800 mg followed by 400 mg 8 hourly usually for about 7 days.
Child: <8 weeks 15 mg/kg once daily or divided into 7.5 mg/kg 12 hourly. >8 weeks to 12 years 20-30 mg/kg as a single dose or divided into 7.5 mg/kg 8 hourly for 7 days. The daily dose may be increased to 40 mg/kg based on the severity of the infection.
Child: <8 weeks 15 mg/kg once daily or divided into 7.5 mg/kg 12 hourly. >8 weeks to 12 years 20-30 mg/kg as a single dose or divided into 7.5 mg/kg 8 hourly for 7 days. The daily dose may be increased to 40 mg/kg based on the severity of the infection.
Oral
Bacterial vaginosis
Adult: 400 mg bid for 5-7 days. Alternatively, 2,000 mg as single dose.
Rectal
Anaerobic infections
Adult: As supp: 1 g 8 hourly for 3 days, then reduce to 12 hourly if needs to continue for more than 3 days. Substitute oral therapy as soon as possible.
Child: <1 year 125 mg; 1-5 years 250 mg; >5-10 years 500 mg. All doses to be given 8 hourly for 3 days, then 12 hourly until oral medication is possible. >10 years Same as adult dose.
Child: <1 year 125 mg; 1-5 years 250 mg; >5-10 years 500 mg. All doses to be given 8 hourly for 3 days, then 12 hourly until oral medication is possible. >10 years Same as adult dose.
Rectal
Prophylaxis of postoperative anaerobic bacterial infections
Adult: As supp: 1 g 2 hours before surgery, repeated 8 hourly until oral doses can be given to complete the 7-day treatment course.
Child: 5-10 years 500 mg supp 2 hours before surgery, repeated 8 hourly for 3 days, then 12 hourly until oral medication becomes possible. >10 years Same as adult dose.
Child: 5-10 years 500 mg supp 2 hours before surgery, repeated 8 hourly for 3 days, then 12 hourly until oral medication becomes possible. >10 years Same as adult dose.
Topical/Cutaneous
Rosacea
Adult: As 0.75% gel/cream/lotion: Apply thinly to the affected area twice daily. Average treatment period: 3-4 months, may be continued for further 3-4 months may be necessary depending on the severity of the infection.
Vaginal
Bacterial vaginosis
Adult: Each applicator delivers approx 5 gm gel containing 37.5 mg metronidazole: 1 applicator-full once daily at bedtime for 5 days.
