Metipranolol

Ophthalmic
Ocular hypertension, Open-angle glaucoma

Bronchial asthma or history of bronchial asthma, severe COPD, symptomatic sinus bradycardia, 2nd or 3rd degree AV block, cardiogenic shock, overt cardiac failure.

Patients w/ myasthenia gravis, a history of cardiac failure or psychiatric disease, DM, cerebrovascular insufficiency, peripheral vascular disease including Raynaud's syndrome. Avoid abrupt withdrawal in patients undergoing elective surgery. May mask certain signs and symptoms of hyperthyroidism. Pregnancy and lactation.

Transient local discomfort, abnormal vision, conjunctivitis, conjunctival leucoplakia, blepharitis, blurred vision, browache, oedema, eyelid dermatitis, photophobia, tearing, uveitis; hypersensitivity reaction, rash, angina, atrial fibrillation, MI, palpitation, bradycardia, anxiety, depression, HTN, dizziness, headache, nervousness, somnolence, asthenia, arthritis, myalgia, bronchitis, cough, dyspnoea, rhinitis, epistaxis, nausea.

Ophth: C

Metipranolol contains benzalkonium Cl which may be absorbed by soft contact lenses. Remove lens prior to admin and wait 15 min before reinserting.

Potential additive effects on systemic β-blockade w/ oral β-blockers. Possible additive hypotensive effects or bradycardia w/ catecholamine-depleting drugs (e.g. reserpine). Possible precipitation of left ventricular failure w/ Ca channel blockers. Concomitant use w/ digitalis and Ca channel blockers may cause additive prolonging effects on AV conduction time.

Description: Metipranolol is a non-cardioselective β-blocker w/o significant intrinsic sympathomimetic activity and membrane-stabilising properties. It has weak local anaesthetic and myocardial depressant activity. It reduces intraocular pressure appears to be via decreased production of aqueous humour.
Onset: ≤30 min.
Duration: Intraocular pressure reduction: Up to 24 hr.

Store between 15-30°C.

Antiglaucoma Preparations

Anon. Metipranolol. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com.

Buckingham R (ed). Metipranolol. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com.

Metipranolol (Bausch & Lomb Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/.

Wickersham RM. Metipranolol. Facts and Comparisons [online]. St. Louis, MO. Wolters Kluwer Clinical Drug Information, Inc. https://www.wolterskluwercdi.com/facts-comparisons-online/.