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Repigmentation of vitiliginous areas
Adult: 20 mg or up to 600 mcg/kg 2-4 hr before measured periods of UVA exposure depending on the preparation, given twice wkly or on alternate days, w/ at least 48-hr intervals.
Oral
Psoriasis
Adult: Up to approx 600 mcg/kg, given 1.5-3 hr before UVA exposure, depending on the preparation. Treatment is usually given twice wkly or increased as necessary, w/ at least 48-hr intervals between doses. If there is no or minimal response after the 15th PUVA treatment, dose may be increased by 10 mg and this dose used for the remainder of the treatment course.
Topical/Cutaneous
Psoriasis
Adult: As a 0.15% soln (diluted to 0.015%, if necessary): Apply to affected areas 15 min before UVA exposure. Alternatively, patient may take a whole body bath in methoxsalen soln for 15 min followed by immediate UVA exposure. For treating affected areas, immerse the affected areas for 15 min into 3 mg/L soln of hand and foot soaks followed by a 30-min delay before UVA exposure. Baths or soaks are given twice wkly.
Topical/Cutaneous
Repigmentation of vitiliginous areas
Adult: As 1% soln (diluted to 0.1-0.01%): Apply over lesions then expose to UVA immediately after application or wait up to 2 hr. Protect the area surrounding the lesion w/ a sunscreen. Wash and protect lesions from light after treatment; protection may be up to ≥48 hr. Treatment is usually repeated once wkly. Substantial repigmentation usually requires 6-9 mth of treatment.
