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Caution must be exercised in Parkinsonians treated with levodopa, as Metadoxil may antagonize the drug's effect.
Metadoxil ampoules contain sodium metabisulfite. This substance may cause allergic reactions and severe asthmatic attacks in sensitive patients, particularly in asthmatics.
Use in pregnancy & lactation: Metadoxil should not be administered during pregnancy and lactation.
Caution when used in patients with CHF especially those with unstable or acute heart failure. Risk of lactic acid accumulation increases with the degree of renal impairment. May need to discontinue treatment in patients with stress-related states e.g. fever, trauma, infection or surgery. Metformin should be temporarily discontinued for 48 hr in patients undergoing radiologic studies involving intravascular admin of iodinated contrast materials. Elderly. Monitor renal function regularly. May impair ability to drive or operate machinery.
