Metadoxil Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Side Effects Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing Brand Resources

Concise Prescribing Info

Contents

Metadoxine

Indications/Uses

Acute alcohol intoxication. Supportive treatment of acute & chronic liver diseases, alcoholic fatty liver.

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Dosage/Direction for Use

Adult Acute ethanol intoxication 500-1,000 mg daily. Alcoholic fatty liver, supportive treatment of acute & chronic liver diseases 1,000 mg daily.

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Overdosage

View Metadoxil overdosage for action to be taken in the event of an overdose.

Contraindications

Hypersensitivity.

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Special Precautions

CHF w/ unstable or acute heart failure. Risk of lactic acid accumulation increases w/ the degree of renal impairment. Discontinue treatment in patients w/ stress-related states eg, fever, trauma, infection or surgery. Temporarily discontinue metformin for 48 hr in patients undergoing radiologic studies involving intravascular administration of iodinated contrast materials. Monitor renal function regularly. May impair ability to drive or operate machinery. Pregnancy & lactation. Elderly.

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Use In Pregnancy & Lactation

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Adverse Reactions

Anorexia, nausea, vomiting, diarrhoea, wt loss, flatulence, occasional metallic taste; weakness; hypoglycaemia; rash, malabsorption of vit B₁₂; chest discomfort, flushing, palpitation, chills, Potentially Fatal: Lactic acidosis in presence of renal failure & alcoholism.

Drug Interactions

Additive effect w/ sulphonylurea. May affect glycaemic control w/ diuretics, corticosteroids, phenothiazines, thyroid products, oestrogens, OCs, phenytoin, nicotinic acid, sympathomimetics, Ca channel blockers, chlorpromazine & INH. Increased metformin effects by ACE inhibitors, disopyramide, MAOIs. Cimetidine may increase serum levels of metformin. Increased risk of metformin-induced lactic acidosis w/ concurrent use w/ contrast agents. May decrease anticoagulant effect of phenprocoumon; routine anticoagulant monitoring is recommended. Potentially fatal: Lactic acidosis w/ alcohol. Thrombocytopenia w/ ketotifen.

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Storage

View Metadoxil storage conditions for details to ensure optimal shelf-life.

Description

View Metadoxil description for details of the chemical structure and excipients (inactive components).

Action

View Metadoxil mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Cholagogues, Cholelitholytics & Hepatic Protectors

ATC Classification

A05BA09 - metadoxine ; Belongs to the class of drugs used in liver therapy.

Regulatory Classification

POM

Presentation/Packing

Form

Metadoxil FC tab 500 mg

Packing/Price

5 × 6's

Metadoxil

metadoxine

Manufacturer:

Micro Labs

Distributor:

Zizawa Healthcare