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Indications and Dosage
Oral
Allergic conditions Adult: 5 mg bid.
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Contraindications
Severe liver disease; premature infants or full-term neonates.
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Special Precautions
Pregnancy, lactation; severe CV disorders; asthma; angle-closure glaucoma, urinary retention, prostatic hyperplasia, pyloroduodenal obstruction; renal and hepatic impairment; elderly, children; epilepsy. May impair ability to drive or operate machinery.
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Adverse Reactions
CNS depression including slight drowsiness to deep sleep, lassitude, dizziness, incoordination. Headache, psychomotor impairment and antimuscarinic effects. Rarely, rashes and hypersensitivity reactions, blood disorders, convulsions, sweating, myalgia, paraesthesias, extrapyramidal effects, tremor, confusion, sleep and GI disturbances, tinnitus, hypotension, hair loss. Photosensitivity, jaundice.
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Drug Interactions
Enhanced effects of CNS depressants e.g. alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives and antipsychotics. Can mask signs of ototoxicity caused by aminoglycosides. QT prolongation reported with spiramycin.
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Lab Interference
May interfere with skin testing.
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Action
Description: Mequitazine is a phenothiazine derivative having antihistaminic, antimuscarinic and mild sedative properties.
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MIMS Class
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