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Indications and Dosage
Topical/Cutaneous
Hypersensitivity reactions, Pruritic skin disorders Adult: As 2% cream: Apply sparingly onto affected area(s) 2-3 times daily for up to 3 days.
Child: ≥2 yr Same as adult dose. |
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Contraindications
Application to eczematous skin conditions or extensively broken skin surfaces.
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Special Precautions
Childn. Pregnancy and lactation.
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Adverse Reactions
Significant: Rarely, skin sensitisation.
Immunologic: Local hypersensitivity reactions. |
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Patient Counseling Information
Avoid contact on large areas of skin, broken, sunburnt, cut or grazed skin. This drug may cause somnolence and mild disorientation, if affected, do not drive or operate machinery.
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Action
Description: Mepyramine is an ethylenediamine derived antihistamine w/ anti-pruritic and local analgesic action. It competitively blocks histamine at H1 receptor sites thus inhibiting the effect of histamine in the body.
Pharmacokinetics: Absorption: Readily absorbed through the skin. Metabolism: Metabolised in the liver. Excretion: Mainly via urine as metabolites. |
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Chemical Structure
 Source: National Center for Biotechnology Information. PubChem Database. Pyrilamine, CID=4992, https://pubchem.ncbi.nlm.nih.gov/compound/Pyrilamine (accessed on Jan. 22, 2020) |
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Storage
Store below 25°C.
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ATC Classification
D04AA02 - mepyramine ; Belongs to the class of topical antihistamines used in the treatment of pruritus.
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References
Bite and Sting Relief Antihistamine Cream Boots Bite & Sting Relief 2 Years Plus Antihistamine Cream (The Boots Company PLC). MHRA. https://products.mhra.gov.uk/. Accessed 19/07/17. Buckingham R (ed). Mepyramine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 19/07/17. Sanofi-Aventis New Zealand Limited. Anthisan Cream data sheet 5 May 2014. Medsafe. http://www.medsafe.govt.nz/. Accessed 19/07/17.
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