Medrogestone: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Myanmar prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Menopausal hormone replacement therapy, Menstrual disorders

Adult: 5-10 mg daily in a cyclical regimen.

Contraindications

Undiagnosed vaginal bleeding, severe hepatic impairment, arterial disease, porphyria, pregnancy testing, pregnancy.

Special Precautions

CV or renal impairment, DM, asthma, epilepsy, migraines, history of depression, conditions which may be aggravated by fluid retention. Lactation.

Adverse Reactions

GI disturbances, changes in appetite or weight, oedema, acne, chloasma, breast changes, hirsutism, headache, changes in serum lipids.

Drug Interactions

Enzyme-inducing drugs may enhance clearance. May inhibit ciclosporin metabolism. Antidiabetic dosage may need to be adjusted.

Action

Description: Medrogestone is a progestogen related to progesterone. It is used in hormone replacement therapy and menstrual disorders and has been used in the past for breast cancer, cancer of the endometrium and prostatic hyperplasia.

MIMS Class

Oestrogens, Progesterones & Related Synthetic Drugs

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