Medoxycin Adverse Reactions

Administration of oxytocin in high doses or to those hypersensitive to it may cause violent uterine contractions leading to uterine rupture and extensive laceration of the soft tissue, fetal bradycardia, fetal arrhythmias, and fetal asphyxiation, and perhaps fetal or maternal death.
Maternal deaths from severe hypertension and subarachnoid haemorrhage have occurred. Postpartum haemorrhage and fatal afibrinogenaemia have been reported but may be due to obstetric complications. Water retention leading to hyponatremia and intoxication, with pulmonary oedema, convulsions, coma, and even death may occur, especially when oxytocin is given intravenously over prolonged periods. Vasopressin-like activity is more likely with oxytocin of natural origin but may occur even with the synthetic peptide.
Anaphylactic and other hypersensitivity reactions, cardiac arrhythmias, pelvic haematomas, and nausea and vomiting may occur. Rapid intravenous injection has produced acute transient hypotension, together with flushing and reflex tachycardia.
There are reports of neonatal jaundice and retinal haemorrhage associated with the use of oxytocin in the management of labour. Adverse effects following the intranasal administration of oxytocin have included nasal irritation, rhinorrhoea, lachrymation, uterine bleeding, and violent uterine contractions.