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Indications and Dosage
Oral
Short-term management of anxiety Adult: As short-term treatment: 10-30 mg daily in divided doses. Severe conditions: Up 60 mg daily.
Elderly: and debilitated patients: Dose reductions required. |
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Contraindications
Glaucoma.
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Special Precautions
Severe hepatic impairment. Elderly or debilitated patients; muscle weakness or myasthenia gravis; impaired liver or kidney function; predisposition to seizures; depression; severe respiratory dysfunction; sleep apnoea; movement disorders; drowsiness may affect skilled tasks; history of alcohol or drug addiction. Treatment withdrawal should be gradual. Avoid long-term use. Pregnancy and lactation.
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Adverse Reactions
Fatigue, drowsiness, dizziness, prolonged reaction time, headache, coordination disorders (ataxia), confusion, anterograde amnesia. Rarely, GI symptoms, laryngeal spasm, chest pain, hypotension, bradycardia, depression, decreased libido, increased appetite, dry mouth, muscle weakness, respiratory failure.
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Drug Interactions
Additive CNS depression or sedative effects with drugs that have CNS depressant properties e.g. alcohol, antidepressants, sedating antihistamines, antipsychotics, general anaesthetics, other hypnotics or sedatives, opioid analgesics, cisapride.
Potentially Fatal: Increased risk of toxicity with hepatic microsomal enzyme inhibitors. |
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Action
Description: Medazepam is a long-acting benzodiazepine used for the short-term treatment of anxiety disorders.
Pharmacokinetics: Absorption: Absorbed rapidly from the GI tract (oral); peak plasma concentrations after 1-2 hr. Metabolism: Hepatic; metabolised to diazepam and desmethyldiazepam. |
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MIMS Class
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