Mabron Side Effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.
The patient should see a doctor immediately if they experience symptoms of an allergic reaction such as swollen face, tongue and/or throat, and/or difficulty swallowing or hives together with difficulties in breathing.
The most common side effects during treatment with Mabron are nausea and dizziness, which occur in more than 1 in 10 people.
Very common: may affect more than 1 in 10 people: dizziness; feeling sick (nausea).
Common: may affect up to 1 in 10 people: headaches, drowsiness; fatigue; constipation, dry mouth, being sick (vomiting); sweating (hyperhidrosis).
Uncommon: may affect up to 1 in 100 people: effects on the heart and blood circulation (pounding of the heart, fast heartbeat, feeling faint or collapse). These adverse effects may particularly occur in patients in an upright position or under physical strain; urge to be sick (retching), stomach trouble (e.g. feeling of pressure in the stomach, bloating), diarrhoea; skin reactions (e.g. itching, urticaria).
Rare: may affect up to 1 in 1,000 people: allergic reactions (e.g. difficulty in breathing, wheezing, swelling of skin) and shock (sudden circulation failure) have occurred in very rare cases; slow heartbeat; increase in blood pressure; abnormal sensations (e.g. itching, tingling, numbness), trembling, epileptic fits, muscle twitches, uncoordinated movement, transient loss of consciousness (syncope), speech disorders; epileptic fits have occurred mainly at high doses of tramadol or when tramadol was taken at the same time as other medicines which may induce fits; changes in appetite; hallucination, confusional state, sleep disorders, delirium, anxiety and nightmares; psychological complaints may appear after treatment with Mabron. Their intensity and nature may vary (according to the patient's personality and length of therapy). These may appear as a change in mood (mostly high spirits, occasionally irritated mood), changes in activity (slowing down but sometimes an increase in activity) and decreased cognitive and sensory perception (being less aware and less able to make decisions, which may lead to errors in judgement); Drug dependence may occur. If Mabron is taken over a long period of time dependence may occur, although the risk is very low. When treatment is stopped abruptly, signs of withdrawal may appear (see "If the patient stops using Mabron under Dosage & Administration"); blurred vision, excessive dilation of the pupils (mydriasis), constriction of the pupil (miosis); slow breathing, shortness of breath (dyspnoea); worsening of asthma has been reported, however it has not been established whether it was caused by tramadol. If the recommended doses are exceeded, or if other medicines that depress brain function are taken at the same time, breathing may slow down; weak muscles; passing urine with difficulty or pain, passing less urine than normal (dysuria).
Very rare: may affect up to 1 in 10,000 people: hepatic enzyme increased.
Not known: frequency cannot be estimated from the available data: decrease in blood sugar level; low sodium concentration in the blood (hyponatremia).
Reporting of side effects: If the patient gets any side effects, talk to the doctor or pharmacist. This includes any possible side effects not listed in this monograph. The patient can also report side effects directly to the Pharmaceutical Services, Ministry of Health. By reporting side effects the patient can help provide more information on the safety of this medicine.