Mabron Dosage/Direction for Use

Always use this medicine exactly as the doctor or pharmacist has told. Check with the doctor or pharmacist if the patient is not sure.
The dosage should be adjusted to the intensity of the pain and the individual pain sensitivity. In general the lowest pain-relieving dose should be received. Normally, daily doses up to 8 ml of Mabron solution for injection (equivalent to 400mg tramadol hydrochloride) will be sufficient. Exceptionally, if clinically required, the doctor may direct to use a higher daily dose.
Unless otherwise prescribed by the doctor, the usual dose is: Adults: Depending on the pain, the patient will receive 1-2 ml of Mabron (equivalent to 50 - 100 mg tramadol hydrochloride).
Depending on the pain, the effect lasts for about 4-8 hours.
The doctor may prescribe a different, more appropriate dosage of Mabron.
Use in children and adolescents: Adolescents from the age of 12 years: as for adults.
Children from the age of 1 year: the usual single dose is 1 - 2 mg tramadol hydrochloride per kg body weight. The lowest analgesically effective dose should generally be selected.
Daily doses of 8 mg tramadol hydrochloride per kg body weight or 400 mg tramadol hydrochloride, whichever is lower, should not be exceeded per day.
Elderly: In elderly patients (above 75 years) the excretion of tramadol may be delayed. If this applies to the patient, the doctor may recommend to prolong the dosage interval.
Severe liver or kidney disease (insufficiency)/dialysis patients: Patients with severe liver and/or kidney insufficiency should not take Mabron.
If in case the insufficiency is mild or moderate, the doctor may recommend prolonging the dosage interval.
How and when should the patient receive Mabron: Mabron will be injected slowly usually into a blood vessel under the surface of the arm or injected into muscle (usually the buttocks) or under the skin. Alternatively, Mabron will be diluted and infused into a vein.
How long should the patient take Mabron: The patient should not receive Mabron for longer than necessary.
If the patient needs to be treated for a longer period, the doctor will check at regular short intervals (if necessary with breaks in treatment) whether the patient should continue to receive Mabron and at what dose.
If the patient has the impression that the effect of Mabron is too strong or too weak, talk to the doctor or pharmacist.
If the patient uses more Mabron than they should: If the patient has received an additional dose by mistake, this will generally have no negative effects. The patient should receive the next dose as prescribed.
If the patient (or someone else) receives a very high dose of Mabron they should go to the hospital or call a doctor straight away.
Signs of an overdose include very small pupils, being sick, fall in blood pressure, fast heartbeat, collapse, unconsciousness, fits and breathing difficulties or shallow breathing.
If the patient forgets to use Mabron: If the patient does not receive Mabron, pain is likely to return. The patient should not receive a double dose to make up for forgotten individual doses, simply continue receiving Mabron as before.
If the patient stops using Mabron: If treatment with Mabron is interrupted or finished too soon, pain is likely to return. If the patient wishes to stop treatment on account of unpleasant effects, tell the nurse or doctor.
Generally there will be no after-effects when treatment with Mabron is stopped. However, on rare occasions, people who have been treated with Mabron for some time may feel unwell if the treatment is abruptly stopped. They may feel agitated, anxious, nervous or shaky. They may be hyperactive, have difficulty sleeping and have stomach or bowel disorders. Very few people may get panic attacks, hallucinations, unusual perceptions such as itching, tingling and numbness, and "ringing" in the ears (tinnitus).
Further unusual CNS symptoms, i.e. confusion, delusions, change of perception of the own personality (depersonalisation), and change in perception of reality (derealisation) and delusion of persecution (paranoia) have been seen very rarely. If the patient experiences any of these complaints after stopping Mabron, tell the nurse or doctor.
If the patient has any further questions on the use of this medicine, ask the doctor or pharmacist.