Generic Medicine Info
Indications and Dosage
Cranial diabetes insipidus
Adult: Per spray contains approximately 0.007 mg lypression (equivalent to 2 Posterior Pituitary Units): 1-2 sprays in each nostril 4 times daily.
Child: Per spray contains approximately 0.007 mg lypression (equivalent to 2 Posterior Pituitary Units): ≥6 wk: 1-2 sprays in each nostril 4 times daily.
Chronic nephritis with nitrogen retention.
Special Precautions
Hypertension or conditions which can be exacerbated by increased BP; nasal absorption may be impaired in rhinitis. Pregnancy.
Adverse Reactions
Nasal congestion, irritation, ulceration. Hypersensitivity reactions. Large doses: Marked pallor, pounding headache, vertigo, sweating, tremor, GI disturbances, eructation, cramp, desire to defaecate; hyponatraemia.
Drug Interactions
Antidiuretic effects increased with chlorpropamide, clofibrate, carbamazepine, fludrocortisone, urea, TCAs. Effects reduced with lithium, heparin, demeclocycline, noradrenaline, alcohol. Ganglion-blocking agents may enhance sensitivity to pressor effects of lypressin.
Description: Lypressin is a synthetic polypeptide with vasoconstrictor and antidiuretic effects.
Onset: Nasal route: Within 1 hr; time to peak: 30-120 minutes.
Duration: Nasal route: 3-4 hr.
Absorption: Rapid from the nasal mucosa.
Metabolism: Renal and hepatic pathways.
Excretion: Half-life: About 15 minutes.
Store between 15-30°C.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Lypressin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by
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