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Indications and Dosage
Oral
Susceptible infections Adult: 408 mg bid. May increase to 1,224-1,632 mg over 24 hr in severe infections. Child: ≥12 yr Same as adult dose. Oral Acne Adult: 408 mg daily continued for at least 8 wk.
Child: ≥12 yr Same as adult dose. |
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Administration
Should be taken on an empty stomach. Take 1 hr before or 2 hr after meals.
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Contraindications
Hypersensitivity to lymecycline or other tetracyclines. Overt renal insufficiency. Pregnancy and lactation. Concomitant use w/ methoxyflurane or oral retinoids.
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Special Precautions
Patient w/ myasthenia gravis. May exacerbate SLE. Hepatic impairment.
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Adverse Reactions
Anaphylaxis, angioedema, blood disorders, exfoliative dermatitis, hepatotoxicity, hypersensitivity reactions, pancreatitis, pericarditis, photosensitivity, rash, Stevens-Johnson syndrome, urticaria; antibiotic-associated colitis, benign intracranial HTN, bulging fontanelles, diarrhoea, dysphagia, headache, oesophageal irritation, visual disturbances, vomiting, dental staining, enamel hypoplasia.
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Patient Counseling Information
This drug may cause photosensitivity reactions, avoid exposure to direct sunlight and UV light.
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Monitoring Parameters
Monitor lymecycline serum levels.
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Drug Interactions
Decreased absorption w/ Ca, Al, Mg, bismuth and zinc salts, antacids, bismuth containing ulcer-healing drugs, Fe preparations and quinapril. Increased effects of anticoagulants. Decreased plasma levels w/ barbiturates, phenytoin or carbamazepine.
Potentially Fatal: Increased risk of kidney failure w/ methoxyflurane. Increased risk of benign intracranial HTN w/ oral retinoids. |
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Lab Interference
May cause false-positive urine glucose determinations. May also interfere w/ fluorometric determinations of urine catecholamines resulting in falsely increased values (Hingerty's method).
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Action
Description: Lymecycline is a tetracycline derivative which blocks the access of bacterial aminoacyl-tRNA to the mRNA-ribosome complex by binding to the 30S ribosome subunit, preventing the addition of amino acids to the growing peptide chain in protein synthesis.
Pharmacokinetics: Absorption: Readily absorbed from the GI tract. Time to peak plasma concentration: W/in 3-4 hr. Distribution: Distributed in most body tissues and fluids, and notably in the lungs, bones, muscles, liver, bladder, prostate, bile and urine. Crosses the placenta and enters breast milk. Excretion: Mainly via urine and secondarily in the bile. Plasma half-life: Approx 10 hr. |
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Chemical Structure
 Source: National Center for Biotechnology Information. PubChem Database. Lymecycline, CID=54707177, https://pubchem.ncbi.nlm.nih.gov/compound/Lymecycline (accessed on Jan. 22, 2020) |
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Storage
Store below 25°C. Protect from light.
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MIMS Class
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ATC Classification
J01AA04 - lymecycline ; Belongs to the class of tetracyclines. Used in the systemic treatment of infections.
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References
Buckingham R (ed). Lymecycline. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 31/03/2016. Joint Formulary Committee. Lymecycline. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 31/03/2016.
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