Lutetium (177lu) oxodotreotide - intravenous

Patient Medicine Information
Why do I need this medicine?
Lutetium (177Lu) oxodotreotide is used to treat certain type of tumours that formed in the pancreas or in other parts of the digestive system such as the stomach, small intestine, colon, rectum, or appendix, which have spread in the body and cannot be removed by surgery.
How do I use this medicine?
Lutetium (177Lu) oxodotreotide injection is to be given intravenously (into the vein). It is delivered directly into the bloodstream via the blood vessel.

Your doctor or nurse will administer the injection for you.

Other medicines may also be used before, during, or after your treatment with Lutetium (177Lu) oxodotreotide. Your doctor will inform you about this.

Your doctor will advise you on the treatment timeframe and other special precautionary instructions after receiving this medicine.
What should I do if I have forgotten to use this medicine?
Ensure that you keep all appointments with your doctor so that you do not miss any doses. Your doctor also needs to regularly monitor your response to Lutetium (177Lu) oxodotreotide.

If you miss an appointment or miss an injection, alert your doctor or nurse. A replacement appointment or injection should be given as soon as possible.
When should I not use this medicine?
Do not use Lutetium (177Lu) oxodotreotide if you are pregnant or planning to have a baby soon. If you become pregnant while being treated with this medicine, alert your doctor immediately. This medicine may cause harm to your unborn child.

It is important that you do not get pregnant while using this medicine. You must use proven birth control methods during Lutetium (177Lu) oxodotreotide therapy and for a minimum of 6 months after stopping the treatment. You may wish to discuss other reliable methods of birth control with your doctor.

Males who have female partners who can get pregnant must also use effective birth control methods during therapy and for 4 months or 6 months after stopping the treatment. You may wish to discuss birth control methods with your doctor.

Do not breastfeed while you are being treated with this medicine and for 2 and a half months after the last dose.
What should I take note of while using this medicine?
Inform your doctor if you have the following conditions:
  • have received anticancer treatment (chemotherapy)
  • have had other types of cancer within the last 5 years
  • have received any radiation therapy (radionuclide)
  • tumour that has spread to the brain or bones
  • inability to control urination
  • blood count problems
  • mild to moderate kidney disease
  • liver disease
Due to the radiation risk from Lutetium (177Lu) oxodotreotide, you will be isolated from other patients who are not receiving the same therapy. Your doctor will inform you when you can leave the controlled area or the hospital. You will be given instructions on how to minimise the risk of radiation exposure to your family members and other people.

Why is it important to keep my appointments with the doctor?

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
  • Pregnancy tests must be done before you start the treatment to know if this medicine is suited for you to use.
  • Routine tests (e.g. complete blood count, kidney and liver function tests) may be done while you are being treated with this medicine. Your doctor will advise you about how often you need to have these tests.
  • Regular monitoring of signs or symptoms of new cancer and excessive release of hormones (neuroendocrine tumour crisis) may also be needed.
What side effects could I experience?
Lutetium (177Lu) oxodotreotide may cause any of the following side effects: nausea, vomiting, decreased appetite, hot flushes, dizziness, headache, stomach pain, indigestion, constipation, hair loss, tiredness, muscle pain and spasms, changes in taste sensation, and sleeping problems.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • severe redness of the skin, diarrhoea, shortness of breath
  • unable to pass urine, blood in the urine, change in how much urine is passed
  • yellowing of the skin or eyes, dark coloured urine, swelling in the legs and ankles
This medicine will cause the level of your red blood cells, white blood cells and platelets to drop.

Red blood cells carry oxygen around your body. A fall in the level of red blood cells may make you feel tired and worn out.

White blood cells help your body to fight infections. A fall in the level of your white blood cells may put you at higher risk for infections, such as coughs, colds and flu, which may lead to more serious infections. Avoid crowded places and people who are sick. Alert your doctor if you have a fever or a cough or flu that does not go away.

Platelets help your blood to clot when there is a cut in the skin. A fall in the level of your platelets may put you at risk of bleeding more than usual. Do not take part in activities where you may fall or get injured, such as contact sports. Alert your doctor if you get any unusual bruising (large bruises or several bruises, especially if the bruises appeared on their own) or bleeding that takes a long time to stop (for example, too much bleeding when you floss or brush your teeth).

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I use this with other medicines?
Inform your doctor and pharmacist if you are taking or using any of these medicines:
  • corticosteroids (anti-inflammatory medicines)
  • somatostatin analogues (medicines used to regulate hormones) e.g. octreotide
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements, and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.

As Lutetium (177Lu) oxodotreotide is a radiopharmaceutical, national guidelines must be followed when receiving, handling, and disposing this medicine.
This information is independently developed by MIMS based on lutetium (177lu) oxodotreotide - intravenous and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2024 MIMS. All rights reserved. Powered by
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