Loteprednol: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Myanmar prescribing information.

Generic Medicine Info

Indications and Dosage

Ophthalmic
Postoperative ocular inflammation

Adult: As 0.5% susp: Instill 1-2 drops onto affected eye(s) 4 times daily, beginning 24 hr after surgery and continuing through the 1st 14 days of post-op period. As 0.5% oint: Apply approx ¹/₂ inch ribbon into the conjunctival sac onto the affected eye(s) 4 times daily, beginning 24 hr after surgery and continuing through the 1st 14 days of post-op period. As 0.5% gel: Instill 1-2 drops to the affected eye(s) 4 times daily, beginning 24 hr after surgery and continuing through the 1st 14 days of post-op period.

Ophthalmic
Seasonal allergic conjunctivitis

Adult: As 0.2% susp: Instill 1 drop onto affected eye(s) 4 times daily.

Ophthalmic
Allergic and inflammatory conditions of the eye

Adult: As 0.5% susp: Instill 1-2 drops onto affected eye(s) 4 times daily.

Contraindications

Ocular viral (e.g epithelial herpes simplex keratitis), fungal, and mycobacterial infection.

Special Precautions

Patient w/ glaucoma, history of ocular herpes simplex. Pregnancy and lactation.

Adverse Reactions

Significant: Increased ocular pressure, optic nerve injury, visual acuity and field of vision defect, posterior subcapsular cataract formation, corneal or scleral thinning, delayed wound healing, secondary ocular infection (e.g. bacterial, viral, fungal infection).
Nervous: Headache.
Resp: Pharyngitis, rhinitis.
Ophthalmologic: Application site burning, foreign body sensation, chemosis, anterior chamber inflammation, blurred vision, epiphora, eye discharge, photophobia, visual disturbance, xerophthalmia, conjunctival hyperaemia, corneal oedema, eye pain, blepharitis, conjunctivitis, corneal changes, eye irritation, keratoconjunctivitis, uveitis, conjunctival papillae.
Dermatologic: Pruritus.

Pregnancy Category (US FDA)

Ophth: C

Patient Counseling Information

Remove contact lenses prior to ophth admin and reinsert after 15 min. This drug may cause transient effects on vision, if affected, do not drive or operate machinery.

Monitoring Parameters

Monitor intraocular pressure (if used for >10 days); signs and symptoms of other infections (e.g. fungal).

Drug Interactions

May increase the risk of intraocular pressure w/ cycloplegics and other ocular hypotensive agents.

Action

Description: Loteprednol is a corticosteroid w/ a glucocorticoid activity. It is highly lipid soluble which enhances cell penetration to induce the production of lipocortin protein that modulates the activity of prostaglandin and leukotrienes resulting in the inhibition of inflammatory response.
Onset: W/in 2 hr.
Pharmacokinetics:
Metabolism: Undergoes extensive metabolism into inactive carboxylic acid metabolite.

Chemical Structure

Storage

Store at 15-25°C. Do not freeze.

MIMS Class

Eye Corticosteroids

ATC Classification

S01BA14 - loteprednol ; Belongs to the class of corticosteroids. Used in the treatment of inflammation of the eye.

References

Alrex Suspension Drops (Bausch & Lomd Incorporated). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 06/07/2017.

Anon. Loteprednol Etabonate. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 06/07/2017.

Anon. Loteprednol. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 06/07/2017.

Buckingham R (ed). Loteprednol Etabonate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/07/2017.

Joint Formulary Committee. Loteprednol Etabonate. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/07/2017.

Lotemax Gel (Bausch & Lomd Incorporated). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 06/07/2017.

Lotemax Ointment (Bausch & Lomd Incorporated). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 06/07/2017.

Lotemax Suspension/Drops (Bausch & Lomd Incorporated). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 06/07/2017.

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