The usual starting and maintenance dose is 50 mg once daily for most patients. The maximum antihypertensive effect is achieved 3-6 weeks after initiation of therapy.
The dose may be increase to 100 mg once daily.
For patients with intravascular volume-depletion (e.g. those treated with high-dose diuretics), a starting dose of 25 mg once daily should be considered.
No initial dosage adjustment is necessary for the elderly patients or for patients with renal impairment, including patients on dialysis. A lower dose should be considered for patients with a history of hepatic impairment.
Losartan Potassium may be administered with other antihypertensive agents of a different class.
Losartan Potassium may be administered with or without food.