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Women of childbearing age should ensure adequate contraception.
LOSAPAC is contra-indicated in pregnancy and should be used with care, if at all, during breast-feeding.
LOSAPAC should be used with caution in patients with bilateral renal artery stenosis or stenosis of an artery to a single kidney, aortic valve stenosis or hypertrophic obstructive cardiomyopathy.
Symptomatic hypotension may occur after initiation of LOSAPAC. Reduced doses must be considered in patients with hepatic impairment.
