Losapac Dosage/Direction for Use

Hypertension: Adult Hypertensives: Dosing must be individualized. The usual starting dose of LOSAPAC is 50 mg once daily. A dose of 25 mg may be used in patients with possible depletion of intravascular volume (e.g. patients treated with diuretics) and patients with a history of hepatic impairment. LOSAPAC can be administered once or twice daily with total daily doses ranging from 25 mg to 100 mg.
If the antihypertensive effect measured at trough using once-a-day dosing is inadequate, a twice-a-day regimen at the same total daily dose or an increase in dose may give a more satisfactory response. The effect of losartan is substantially present within one week but in some studies the maximal effect occurred in 3-6 weeks.
If blood pressure is not controlled by losartan alone, a low dose of a diuretic may be added.
No initial dosage adjustment is necessary for elderly patients or for patients with renal impairment, including patients on dialysis.
Pediatric hypertensive patients 6 years or age: The usual recommended starting dose is 0.7 mg/kg once daily (up to 50 mg total). Dosage should be adjusted according to blood pressure response. Doses above 1.4 mg/kg (or in excess of 100 mg) daily have not been studied in pediatric patients. Losartan is not recommended in pediatric patients <6 years of age or in pediatric patients with glomerular filtration rate <30mL/min/1.73m.
Hypertensive patients with left ventricular hypertrophy: The usual starting dose is 50 mg once daily. Hydrochlorothiazide 12.5 mg daily should be added and/or the dose of LOSAPAC should be increased to 100 mg once daily followed by an increase in hydrochlorothiazide to 25 mg once daily based on blood pressure response.
Nephropathy in type 2 diabetic patients: The usual starting dose is 50 mg once daily. The dose should be increased to 100 mg once daily based on blood pressure response.