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Patients with hepatic impairment or renal insufficiency (e.g. glomerular filtration rate less than 30 mL/minute), including geriatric patients, have decreased clearance of the drug, and should be given a lower initial dose of loratadine.
Patients should be advised to discontinue loratadine therapy immediately and to contact the doctor if any signs of an allergic reaction occur.
Effects on ability to drive and use machines: Loreze has influence on ability to drive and use machines. Sedation (e.g. drowsiness, fatigue) occurred in about 12% (e.g. 8 and 4% respectively) of patients receiving loratadine in clinical trials. The incidence of drowsiness appears to be dose related; although the incidence of drowsiness in patients receiving 10 mg of loratadine is no greater than that in patients receiving placebo, dose-related drowsiness becomes more prominent with doses of 20-40 mg.
