The acute lethal dose of loratadine in humans is not known. In adults, drowsiness, tachycardia, and headache have been reported after overdoses (e.g. 40-180 mg) of loratadine tablets. Treatment of loratadine overdosage generally involves symptomatic and supportive care, initiated promptly and maintained as long as necessary. In acute loratadine overdosage, the stomach should be emptied immediately by inducing emesis with ipecac syrup. Administration of activated charcoal after emesis may be useful in preventing absorption of loratadine.