OralShort-term management of insomniaAdult: 1 mg at bedtime. May increase to 1.5 mg or 2 mg if necessary. Max duration: 4 wk. Elderly: Initially, 0.5 mg at bedtime. Max: 1 mg.
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Debilitated patients: Initially, 0.5 mg at bedtime. Max: 1 mg.
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Acute pulmonary insufficiency, severe resp insufficiency, myasthenia gravis, phobic or obsessional states and sleep apnoea syndrome. Monotherapy in depression or anxiety associated w/ depression and chronic psychosis and alcohol intake.
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Patient w/ personality disorders, history of alcoholism or drug abuse, chronic pulmonary insufficiency, cerebrovascular disease. Avoid abrupt withdrawal. Chronic renal or hepatic impairment. Elderly and debilitated patients. Pregnancy and lactation.
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Headache, nausea, drowsiness, hypotonia, blurred vision, dizziness, ataxia. Rarely, paradoxical aggressive outbursts, excitement, confusion and uncovering of depression w/ suicidal tendencies; hypotension, GI and visual disturbances, skin rashes, urinary retention, changes in libido, blood dyscrasias, jaundice.
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This drug may cause drowsiness, sedation, amnesia, impaired concentration and muscular weakness, if affected, do not drive or operate machinery.
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Symptoms: Drowsiness, ataxia, dysarthria, nystagmus, and occasionally, resp depression and coma. Management: Symptomatic treatment. May perform gastric lavage shortly after ingestion. Consider flumazenil as antidote.
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Potentiation by other drugs acting in the CNS or w/ cisapride. Additive synergy w/ neuromuscular depressants (e.g. curare-like drugs and muscle relaxants). Enhanced central depressive effects w/ CNS depressants (e.g. antipsychotics, narcotic analgesics, anaesth).
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Enhanced sedative effects w/ alcohol.
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Description: Loprazolam is an intermediate-acting benzodiazepine which potentiates central inhibitory GABA-mediated transmission.
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Store below 25°C. Protect from light.
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N05CD11 - loprazolam ; Belongs to the class of benzodiazepine derivatives. Used as hypnotics and sedatives.
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Buckingham R (ed). Loprazolam Mesilate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 30/03/2016. Joint Formulary Committee. Loprazolam. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 30/03/2016.
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