Lodoxamide: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Myanmar prescribing information.

Generic Medicine Info

Indications and Dosage

Ophthalmic
Allergic conjunctivitis

Adult: As 0.1% soln: Instill 1-2 drops into affected eye(s) 4 times daily.
Child: ≥4 yr Same as adult dose.

Special Precautions

Childn. Pregnancy and lactation.

Adverse Reactions

Significant: Eye irritation (e.g. burning, stinging, discomfort), blurred vision or visual disturbances.
Nervous: Headache, dizziness, drowsiness, somnolence.
GI: Nausea, stomach discomfort.
Resp: Dry nose, sneezing.
Ophthalmologic: Eye itching, foreign body sensation of eye, dry eye, crystalline eye deposit, lacrimation, ocular hyperaemia, ocular oedema, xerophthalmia, asthenopia, blepharitis, chemosis, corneal abrasion, corneal erosion, corneal ulcer, epitheliopathy, eye pain, keratitis, ocular warming sensation, swelling of eye.
Dermatologic: Skin rash.

Pregnancy Category (US FDA)

Ophth: B

Patient Counseling Information

This drug may cause temporary blurred vision or visual disturbances, if affected, do not drive or operate machinery. Remove contact lenses prior to ophth admin and reinsert after 15 min.

Action

Description: Lodoxamide is a mast cell stabiliser that inhibits release and activation of inflammatory mediators (e.g. histamine, leukotrienes) from conjunctival tissues thus inhibiting type 1 immediate hypersensitivity reactions.
Pharmacokinetics:
Excretion: Mainly via urine, 83%. Elimination half-life: 8.5 hr.

Chemical Structure

Storage

Store below 25°C. Do not freeze.

MIMS Class

Antihistamines & Antiallergics / Ophthalmic Decongestants, Anesthetics, Anti-Inflammatories

ATC Classification

S01GX05 - lodoxamide ; Belongs to the class of other ophthalmologic antiallergics.

References

Anon. Lodoxamide. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 05/07/2017.

Buckingham R (ed). Lodoxamide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 05/07/2017.

Joint Formulary Committee. Lodoxamide. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 05/07/2017.

McEvoy GK, Snow EK, Miller J et al (eds). Lodoxamide Tromethamine (EENT). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 05/07/2017.

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