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Linolid

Linolid

linezolid

Manufacturer:

Kusum

Distributor:

JDS
Concise Prescribing Info
Contents
Linezolid
Indications/Uses
Nosocomial & community acquired pneumonia. Complicated skin & soft tissue infections.
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Dosage/Direction for Use
Adult 600 mg bd for 10-14 consecutive days.
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Overdosage
View Linolid overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Uncontrolled HTN, phaeochromocytoma, carcinoid, thyrotoxicosis, bipolar depression, schizoaffective disorder, acute confusional states. Concomitant use w/ MAOIs (or w/in 2 wk of such therapy); SSRIs, TCAs, serotonin 5-HT1 receptor agonists, directly & indirectly acting sympathomimetic agents, vasopressives, dopaminergics, pethidine or buspirone. Lactation.
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Special Precautions
Monitor myelosuppression. Patients w/ preexisting anaemia, granulocytopenia or thrombocytopenia; concomitant use w/ medications decreasing Hb, depress blood counts or adversely affect platelet count or function. Weekly monitor complete blood counts (including Hb levels, platelets & total & differentiated leukocyte counts). Mortality imbalance in patients w/ catheter-related gm +ve bloodstream infections. Risk of antibiotic-associated diarrhoea & colitis (including pseudomembranous colitis & Clostridium difficile-associated diarrhea); lactic acidosis; mitochondrial dysfunction; serotonin syndrome; peripheral & optic neuropathy; convulsions; superinfection. Excessive consumption of tyramine-rich foods. Do not drive or operate machinery if dizziness or visual impairment occurs. Patients w/ severe hepatic & renal insufficiency (including those undergoing dialysis). Pregnancy. Childn <18 yr.
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Adverse Reactions
Candidiasis, oral candidiasis, vag candidiasis, fungal infections; anaemia; insomnia; headache, taste perversion (metallic taste), dizziness; HTN; diarrhoea, nausea, vomiting, localised or general abdominal pain, constipation, dry mouth, dyspepsia; abnormal liver function test, increased AST, ALT or alkaline phosphatase; pruritus, rash; increased BUN; fever, localised pain; increased LDH, creatine kinase, lipase, amylase or non-fasting glucose; decreased total protein, albumin, Na or Ca; increased or decreased K or bicarbonate.
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Drug Interactions
MAOIs. Increased BP caused by pseudoephedrine & phenylpropanolamine HCl. Potential serotonergic interaction w/ dextromethorphan. Avoid excessive amounts of tyramine-rich foods. Decreased Cmax & AUC w/ rifampicin. Reduced mean max & AUC INR w/ warfarin.
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Storage
View Linolid storage conditions for details to ensure optimal shelf-life.
Description
View Linolid description for details of the chemical structure and excipients (inactive components).
Action
View Linolid mechanism of action for pharmacodynamics and pharmacokinetics details.
MIMS Class
Other Antibiotics
ATC Classification
J01XX08 - linezolid ; Belongs to the class of other antibacterials. Used in the systemic treatment of infections.
Presentation/Packing
Form
Linolid FC tab 600 mg
Packing/Price
1 × 10's;10 × 10's
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